Social studies of science and technology are dominated by action and macro approaches. This has led to a neglect of institutions and institutional arrangements at the meso level, which are important, in particular to the student of technology. The transfer of concepts and methods from social studies of science to technology studies has conserved this lack of concern with the meso level. This article suggests a more critical evaluation of this transfer, along with a review of the now popular assumption (...) of a high degree of similarity between science and technology. Two case studies show how meso-level considerations are important to an understanding of the nature of technological innovation and illustrate the lack of similarity between scientific and technological development. (shrink)

International companies expanding and competing in an increasingly global context are currently discovering the necessity of sharing knowledge across geographical and disciplinary borders. Yet, especially in such contexts, sharing knowledge is inherently complex and problematic in practice. Inspired by recent contributions in science studies, this paper argues that knowledge sharing in a global context must take into account the heterogeneous and locally embedded nature of knowledge. In this perspective, knowledge cannot easily be received through advanced information technologies, but must always (...) be achieved in practice. Empirically, this paper draws from two contrasting initiatives in a major international oil and gas company for improving its current ways of sharing knowledge between geographically distributed sites and disciplines involved in well planning and drilling. The contrasting cases reveal that while a shared database system failed to improve knowledge sharing across contexts, a flexible arrangement supporting collaboration and use of different representation of knowledge was surprisingly successful. Based on these findings the paper underscores and conceptualizes various triangulating practices conducted in order to achieve knowledge across borders. More accurately these practices are central for individuals’ and communities’ abilities to: (i) negotiate ambiguous information, (ii) filter, combine, and integrate various heterogeneous sources of information, and (iii) judge the trustworthiness of information. Concerning the design and use of information technologies this implies that new designs need to facilitate triangulating practices of users rather than just providing advanced platforms (“digital junkyards”) for sharing information. (shrink)

Utviklingen innenfor informasjons- og kommunikasjonsteknologi har gitt opphav til en type etisk-politisk utfordring som gjerne kalles digital ulikhet. Tradisjonelt har det dreid seg om sosiale ulikheter i tilgangen til IKT på individnivå. Nyere forskning på området er mer opptatt av bruk og dermed av tilbudet av aktiviteter og tjenester gjennom Internett. I denne artikkelen ser vi på hvordan det kan oppstå geografisk digital ulikhet som følge av at norske kommuner tilbyr digitale tjenester – herunder informasjon og ressurser for lokalpolitisk deltakelse (...) – i svært forskjellig omfang. Det betyr at kommunene står overfor etisk-politiske utfordringer knyttet til digital ulikhet som følge av deres strategier for bruk av hjemmesider, og for digital utvikling av kommunen mer generelt. Selv om det er få kommuner som tilbyr særlig mye når det gjelder lokalpolitisk deltakelse, er ulikhetene i tilbudet av informasjon og digitale tjenester betydelige. I tillegg bidrar velutviklede hjemmesider til å gjøre kommunen mer gjennomsiktig og lettere tilgjengelig, noe vi antar er en fordel for innbyggerne. Analysen er basert på en kvantitativt orientert innholdsanalyse av hjemmesidene til alle norske kommuner og en kvalitativ innholdsanalyse av hjemmesidene til ti norske kommuner.Nøkkelord: digital ulikhet, etisk-politiske utfordringer, kommuner, hjemmesider, digitale tjenesterEnglish summary: Norwegian local governments electronically out of step? From social to geographical digital dividesThe development of information and communication technologies has raised a kind of ethical–political challenge usually referred to as a digital divide. Traditionally, this has fomented concerns about social inequalities with respect to individual access to ICT. More recent scholarship argues the need to be more focused on use rather than access; accordingly, also on the supply of activities and services through internet. In this article, we study how geographical digital divides may appear as a consequence of the fact that Norwegian local governments supply digital services – including information and resources for local political participation – to quite a different extent. This means that local governments face ethical–political challenges related to digital divides as a consequence of their strategies for the development of home pages and for digital development of local government services more generally. Even though only a few local governments offer much with regard to local political participation, the inequalities with respect to the supply of information and digital services are considerable. In addition, apparently, well–developed home pages make the local government more transparent and more accessible. We believe this to be of advantage to local citizens. The analysis is based on a quantitative content analysis of all Norwegian local governments and a qualitative content analysis of the home pages of 10 local governments. (shrink)

The problem of developing research and innovation in accordance with society’s general needs and values has received increasing attention in research policy. In the last 7 years, the concept of “Responsible Research and Innovation” has gained prominence in this regard, along with the resulting question of how best to integrate awareness about science–society relations into daily practices in research and higher education. In this context, post-graduate training has been seen as a promising entrance point, but tool-kit approaches more frequently have (...) been used. In this paper, we present and analyze an experiment—in the format of a Ph.D. course for early-career researchers—deploying an alternative approach. Drawing on Argyris and Schön’s framing of reflective practice, and their distinctions between espoused theories and theories-in-use, the analyzed course endeavored to stimulate double-loop learning. Focusing on dislocatory moments, this paper analyses how the course tried to teach participants to reflect upon their own practices, values, and ontologies, and whether this provided them with the resources necessary to reflect on their theories-in-use in their daily practices. (shrink)

Oncogene activation leads to cellular transformation by deregulation of biological processes such as proliferation and metabolism. Paradoxically, this can also sensitize cells to nutrient deprivation, potentially representing an Achilles' heel in early stage tumors. The mechanisms underlying this phenotype include loss of energetic and redox homeostasis as a result of metabolic reprogramming, favoring synthesis of macromolecules. Moreover, an emerging mechanism involving the deregulation of mRNA translation elongation through inhibition of eukaryotic elongation factor 2 kinase (eEF2K) is presented. The potential consequences (...) of eEF2K deregulation leading to cell death under nutrient depletion are discussed. Finally, the relevance of eEF2K as a master regulator of the response to nutrient deprivation in vivo, and its potential exploitation for therapeutic targeting of cancers, are elaborated. Overall, a better understanding of the adaptive mechanisms allowing tumors to circumvent oncogene‐induced hypersensitivity to nutrient deprivation is a promising avenue for uncovering novel therapeutic targets in cancers. (shrink)

Familial clustering of a disease is defined as the occurrence of the disease within some families in excess of what would be expected from the occurrence in the population. It has been demonstrated for several cancer types, ranging from rare cancers as the adenomatosis-coli-associated colon cancer or the Li-Fraumeni syndrome to more common cancers as breast cancer and colon cancer. Familial clustering, however, is merely an epidemiological pattern, and it does not tell whether genetic or environmental causes or both in (...) combination are responsible for the familial clustering. Familial clustering may be due to genetic predisposition to the disease, but exposure to environmental factors — shared by members of some families, but not by members of other families — may also cause familial clustering and hence mimic genetic inheritance in the study of nuclear families. Based on assumptions regarding the individual steps in the biological process starting with exposure to carcinogens and ending with death from disseminated cancer we suggest that genetic and environmental factors may both be involved in most of these steps. The present paper focuses on research methodologies necessary to discriminate between the effect of genes and family environment in the development of cancer. (shrink)

From a tradition of discourse ethics, human dignity can be defined as “being an equal member in the realm of subjects and authorities of justification.” Additionally, “to act with dignity means being able to justify oneself to others; to be treated in accordance with this dignity means being respected as such an equal member.” Conversely, “to treat others in ways that violate their dignity means regarding them as lacking any justification authority”. The guidelines found in Habermas’s “ideal speech situation” are (...) essential to guarantee this notion of human dignity. Based on aspects of Habermas’s, as well as Rainer Forst’s theory of justice, this study analyzes efforts made by the late speaker of Deutsche Bank, Dr. Alfred Herrhausen, and the former CEO of Alcoa and United States Secretary of the Treasury, Paul H. O’Neill, to challenge the way debt crises in the developing world were handled. Both leaders understood indebted countries, the livelihoods and dignity of its citizens, not as an external entity but as an integral part of their agendas. The two agents included underrepresented groups in their considerations and discussions through a proxy or surrogate participation, giving them a greater voice and acknowledging their dignity. (shrink)

My thesis is that you can lie with ‘ P therefore Q ’ without P or Q being lies. For you can lie by virtue of not believing that P supports Q. My thesis is reconciled with the principle that all lies are assertions through H. P. Grice’s account of conventional implicatures. These semantic cousins of conversational implicatures are secondary assertions that clarify the speaker’s attitude toward his primary assertions. The meaning of ‘therefore’ commits the speaker to an entailment thesis (...) even though the speaker does not enter that commitment into the text. Insincere conventional implicatures are akin to insincerely asserted footnotes. An absence of lies in the text is compatible with the presence of lies in the meta-text. (shrink)

Der Kadi und seine Zeugen: Studie der mamlukischen Ḥaram-Dokumente aus Jerusalem. By Christian Müller. Abhandlungen für die Kunde des Morgenlandes, vol. 85. Wiesbaden: Harrassowitz, 2013. Pp x + 647. €79.

Neil D. Jones, Computability and Complexity. From a Programming Perspective.Neil D. Jones, T. AE. Mogensen, Computability by Functional Languages.M. H. Sorensen, Hilbert's Tenth Problem.A. M. Ben-Amram, The Existence of Optimal Algorithms.

Zwei Anlässe bilden den Ausgangspunkt für diesen Sammelband. Anlässlich des 100. Todestags von Hermann Cohen fand im Oktober 2018 in Dortmund ein Symposium statt, das hier dokumentiert wird. Im Mittelpunkt standen hierbei die Fragen nach Cohens Bedeutung für die Philosophiegeschichte bis in die Gegenwart sowie nach der bleibenden Relevanz seines Religionsbegriffs. Zudem wird Dieter Adelmanns grundlegende Studie zum Herkommen des Begriffs „erzeugen“ in Cohens Logik der reinen Erkenntnis aus der Synthese von früher Wissenschaft des Judentums und der Humboldtschen Sprachphilosophie im (...) Werk H. Steinthals erstmals einer breiten Öffentlichkeit vorgelegt. Adelmann zeigt insbesondere die Bedeutung von M. Joel, Michael Sachs und Steinthal für das religiös geprägte Denken des Marburger Neukantianers und Erkenntnistheoretikers Cohen auf. Brigitte Falkenburg zeigt, dass jenseits von Cohens Erkenntnistheorie seine eigentliche Bedeutung im philosophischen Konstruktivismus zu finden ist. Knut Martin Stünkel wendet sich Cohens unterschätzter Religionsschrift Der Begriff der Religion im System der Philosophie von 1915 zu und entwickelt eine Religionstopologie, mit deren Hilfe eine metasprachliche Ebene der Religionsforschung ermöglicht wird. (shrink)

Nonnaturalist realism is the view that normative properties are unique kind of stance-independent properties. It has been argued that such views fail to explain why two actions that are exactly alike otherwise must also have the same normative properties. Mark Schroeder and Knut Olav Skarsaune have recently suggested that nonnaturalist realists can respond to this supervenience challenge by taking the primary bearers of normative properties to be action kinds. This paper develops their response in two ways. First, it provides (...) additional motivation for the previous claim about the bearers of normative properties by drawing from the work of H. A. Prichard. Second, and more importantly, it formulates a plausible metaphysical framework based on the contemporary trope theory to explain why action kinds would have their second-order properties, including their normative properties, necessarily. (shrink)

In order to understand the various strands of general equilibrium theory, why it has taken the forms that it has since the time of Léon Walras, and to appreciate fully a view of the state of general equilibrium theorising, it is essential to understand Walras's work and examine its influence. The first section of this book accordingly examines the foundations of Walras's work. These include his philosophical and methodological approach to economic modelling, his views on human nature, and the basic (...) components of his general equilibrium models. The second section examines how the influence of his ideas has been manifested in the theorising of his successors, surveying the models of theorists such as H. L. Moore, Vilfredo Pareto, Knut Wicksell, Gustav Cassel, Abraham Wald, John von Neumann, J. R. Hicks, Kenneth Arrow, and Gerard Debreu. The treatment also examines models of many types in which Walras's influence is explicitly acknowledged. (shrink)

[ḥeleḳ 1]. Al hilkhot meḳaḥ ṭaʻut, onaʼah u-matanah, Ḥ m. 227-249 -- ḥeleḳ 2. ʻAl Hilkhot avedah u-metsiʼah, hefḳer, periḳah u-ṭeʻinah, genevah u-gezelah, Ḥ. m. 259-275, 348-377.

On the importance of good deeds in Islam.

The doctrine of tyrannicide is a well-known element of John of Salisbury's Policraticus. Although John was not the first Western thinker to propose the legitimacy of tyrannicide, the fact that he was the first to expound the idea fully and explicitly entitles him to be called the “author” of the doctrine insofar as concerns twelfth-century Europe. At various times from the thirteenth to the sixteenth century John is cited as authority by actual and would-be tyrannicides, and is condemned as such (...) by their opponents. jQuery.click { event.preventDefault(); }). (shrink)